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Actinic Keratosis in Japan

  • Actinic Keratosis (AK) in Japan:
    • tend to be multiple
    • 20% evolve into Squamous Cell Carcinoma (SCC)
    • clinical types: macular, horn, papular, actinic cheilitis. All types can be pigmented: atypical keratinocytes containing melanin granules in the cytoplasm



  • Aging of AK and histological caracteristics:
    • early AKs:
      • no parakeratosis
      • atypical keratinocytes limited to the basal layer
      • no budding
    • developed AKs:
      • thick parakeratosis
      • budding in the papillary dermis
    • together with this, histological features of solar damage are also present: solar elastosis



Kimura T. Sundamaged Skin and Skin Cancer. Photodermatosis and Ethnicity in Asian Skin. 2014 (4) – 21st Regional Conference of Dermatology; Danang (Vietnam)

Source of information: here