Atopic Dermatitis is More and more frequent: how the Body Senses the Environment

-In urban settings the prevalence of Eczematous conditions such as Atopic Dermatitis is on the rise.
-This study shows that the dioxin receptor could be implicated in the sensitization process leading to inflammation and subsequent skin lesions.
–One comment to add: Comment Innate lymphoid cells more frequently contain AhR receptor activation (To see article in Dermatologica Helvetica forum, click HERE)

Please see the abstract below (Study from Tohoku (Sendai), Japan)

“Recent epidemiological studies revealed a correlation between rapid increase in the prevalence of atopic dermatitis (AD) and air pollution levels. Polycyclic aromatic hydrocarbons (PAH) were identified as the component responsible for the air  pollutant-induces inflammation. They exert biological effects by binding to a transcription factor, aryl hydrocarbon receptor (AhR). To investigate mechanisms underlying the air pollution-induced AD and concluded that the results suggest  that epicutaneously exposed air pollutants will penetrate through skin and activate AhR in the epidermis, that is one of the possible mechanisms of air pollutant-induces AD…”

The full abstract is available in the Program Book of the Abstract Book of the 41st Annual JSID meeting – Sendai, Japan (page 203)

P10-06 Air pollution activates Aryl hydrocarbon receptor in murine epidermis, leading to Atopic dermatitis-like pathologies. Hidaka T et al. Japanese Society for Investigative Dermatology 2016 – Sendai. Japan