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How is melanin produced ? (melanin is the principal pigment giving to the skin its color)

How is melanin produced ? (melanin is the principal pigment giving to the skin its colour)

  • Tyrosinase is normally inactive and is produced through the transcription of the tyrosinase gene
  • Glycolization (attachment of a sugar) of tyrosinase activates it. Glycolization is induced by sunlight, irritation, hormones, radicals…
  • Activated tyrosinase then converst the amino acid tyrosine to melanin
  • Melanin is then packaged in melanosomes which are then transferred to the surrounding keratinocytes

 

 

Bibliography: Katsambas A. Melasma: Pathogenesis and Treatment. 70e Réunion annuelle de l’AAD (American Academy of Dermatology) – San Diego, California, United States of America (USA)

Original article: here