How is melanin produced ? (melanin is the principal pigment giving to the skin its colour)
- Tyrosinase is normally inactive and is produced through the transcription of the tyrosinase gene
- Glycolization (attachment of a sugar) of tyrosinase activates it. Glycolization is induced by sunlight, irritation, hormones, radicals…
- Activated tyrosinase then converst the amino acid tyrosine to melanin
- Melanin is then packaged in melanosomes which are then transferred to the surrounding keratinocytes
Bibliography: Katsambas A. Melasma: Pathogenesis and Treatment. 70e Réunion annuelle de l’AAD (American Academy of Dermatology) – San Diego, California, United States of America (USA)
Original article: here