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Twice-daily versus once-daily applications of pimecrolimus cream 1% for the prevention of disease relapse in pediatric patients with atopic dermatitis. Ruer-Mulard M, Aberer W et al. Pediatr Dermatol. 2009 Sep-Oct;26(5):551-8.     This article demonstrates that a once... READ MORE

Several genes and environmental factors are implicated but the one gene having the biggest role is filaggrin. This gene will be studied here     Synthesis process of filaggrin (flg): genetic localisation: chromosome 1=epidermal differentiation complex (group of genes... READ MORE

chronic AD which is lichenified is difficult to treat     The 3 major problematic factors with AD are: pruritus flares skin infections (bacterial and viral)     Etiology of AD genetic? environmental ? atopic march ?     In the absence of a definate... READ MORE

Structure of the summary 1. Measuring their efficacy 2. Role of emollients 3. Where is the evidence ?     1.  Measuring their efficacy or the importance of scoring system for physicians SCORAD Objective SCORAD 3 items criteria (more practical and easier to do in daily... READ MORE

Infection prevention avoid rubber, toys: risk of GRAM – folliculitis     Baths in saline 9g Nacl in 1lt (raise to 30-36g NaCl) in KMnO4 1/10000: not on the head (effective, increases pH very slightly (paradoxical) but reduces St Aureus)     Moisturization of... READ MORE

In severe atopic dermatitis (AD), immunosuppressants such as cyclosporine are used. However the latter treatment is expensive especially in countries where a healthcare insurance system is lacking, and that the patient has to pay himself for treatment. 9 cases of children with AD... READ MORE

Atopic dermatitis in older patients: particular points. Katsarou A, Armenaka MC. J Eur Acad Dermatol Venereol. 2010 Jun 21.     Atopic Dermatitis (AD)  is increasing in its frequency mostly due to the phenomenal increase in atopy we have seen in the last 20 years.... READ MORE

Bone mineral density in children with moderate to severe atopic dermatitis. van Velsen SG, Knol MJ, van Eijk RL, de Vroede MA, de Wit TC, Lam MG, Haeck IM, de Bruin-Weller MS, Bruijnzeel-Koomen CA, Pasmans SG. J Am Acad Dermatol. 2010 Nov;63(5):824-31.     Atopic... READ MORE

Apremilast for atopic dermatitis: reversing interleukin-4 dysregulation on primary human keratinocytes (Poster) Mohan GC et al. AAD 2015 Annual Meeting, San Francisco CA – United States     INTRODUCTION Apremilast (Otezla) is an oral treatment for plaque psoriasis. It... READ MORE

Atopic Dermatitis is a chronic inflammatory condition of the skin which affects around 5% of the population. It is more prevalent in children living in industrialized nations with 15-20% affected. Initial presentation is under the age of four in 2/3 of cases. Global pollution and... READ MORE