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Poster: Utility of Intradermally Administered Botulinum Toxin In The Treatment of Macular Amyloidosis (For Professionals)

Observation :

-male patient of 55 years of age, phototype IV

-followed-up for macular amyloidosis (histologically proven) for 4 years, located preesternally, in the interscapular and scapular areas.

-intense nocturnal pruritus (8 on a scale from 0 to 8).

-lesions and pruritus unresponsive to topical steroids, anti-H1 antihistaminics and to 30 treatment sessions of narrow-band UV phototherapy.

-2 weeks after intradermal injections of type A botulinum toxin (Botox) :

  • quantity of 2.5 units of toxin spaced by 2cm.
  • concentration of 25 unites per millilitre of physiologic serum.
  • reduction of pruritus:
  1. from 8/10 to 4/10 in the presternal and interscapular areas.
  2. from 8/10 to 0/10 in the scapular area.
  3. Lasting: no recurrence after 6 months.

 

 

-Comment: no description of an improvement in the clinical appearance of lesions.

Conclusion: symptomatic efficacy of the treatment of macular amyloidosis with botulinum toxin.

 

 

Declared conflicts of interest : non mentioned on the poster

Source of information (French): Poster (Dauendorffer JN et al.). Journées Dermatologiques de Paris 2009.

Original article: here