Psoriasis: Effects of Treatment on Signaling between Involved Cells

In psoriasis, 3 main pathways are involved resulting from the interaction between 3 cells:

• keratinocytes
• dendritic cells
• T lymphocytes

These cells interact closely through paracrine signaling of  chemokines which include cytokines (Interleukines, TNF) and their cellular receptors. (Paracrine refers to close cell to cell communication)

Transcriptome analysis of psoriasis shows up regulation and down regulation of genes which differ between normal keratinocytes and the ones in psoriasis:
-In cytokine-cytokine receptor path analysis, there are differences in expression of Interleukines, TNF alpha and TNF-receptors in lymphocytes (Th1, Th2, Th17 cells, Th9, Th22 , Treg)
-by adding clobetasol (a topical treatment) or methotrexate (an oral treatment), some chemokines as well as their receptors are differently expressed  
-However, the significance of the overexpressed/underexpressed Ils, TNF, TNF receptors is largely unknown

Conclusion: the signaling complex is complex in psoriasis, but differences have been seen when comparing with normal treatments and signaling changes occur happen in vitro when clobetasol and methotrexate treatments are given to psoriatic keratinocytes.

 
Psoriasis pathogenesis: readings from clinical therapeutic results. Min Zheng (China). SY06 – Pathogenesis of Psoriasis – What’s Clinically Relevant? World Congress of Dermatology 2015 –  Vancouver, Canada