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Seborrheic Keratosis – Table of Contents

Seborrheic keratosis=SK


-Historical Features


Clinical Features

-Clinical Presentation

-Differential diagnosis on clinical grounds

Dermatoscopical Features

-Differential Diagnosis on dermoscopical grounds

Histological Features

Association of SK with systemic disease


-Origin of SK

  1. follicular epithelium
  2. solar lentigo

-Causal factors

  1. Uv exposure
  2. HPV infection (Human papillomavirus))
  3. deficiency in presenilin
  4. vitamin A deficiency


Suggested Mechanisms of growth

-By hyperproliferation theory

-Accumulation of senescent cells theory

-Authors’ Experience


-Pigmentation in SK: a mechanism explained by parallelism?


This review was initially written in 2005 and does not include new discoveries like the proposed fgf3 receptor mutation. However, the information is correct and the publications which came out at later dates do not answer in a definite way the questions made by the study of this frequent albeit enigmatic lesion.

This advice is for informational purposes  only and does not replace therapeutic judgement done by a skin doctor.