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The Keratinocyte (cell)

  • Keratinocytes occupy almost all the cells in the epidermis.
  • They are essential for barrier function. To this means they differentiate from live cells to a functional (and very effective) barrier before being shed from the stratum corneum (they are then called keratinocytes).
    • During differentiation, they flatten, strengthen (keratin acting like bricks) and secrete substances which will act as a mortar between them.
    • They are produced by epidermal stem cells located in the Basal Layer.
  • They proliferate faster in conditions such as psoriasis. In pemphigus vulgaris, an autoimmune skin disease, a protein called desmoglein (DSG) is targeted, which usually plays an essential role in the adhesion of keratinocytes with each other. DSG1 is targeted in superficial keratinocytes giving rise to pemphigus foliaceus and DSG2 is targeted in “classical” pemphigus vulgaris.

About Dr Christophe HSU

Dr HSU is an internationally seasoned dermatologist who has lived as an expatriate and who therefore understands the difficulty in finding a like-minded healthcare provider in a sometimes intimidating environment. [(dermatologue) in French]

Read more about Dr HSU (Read in French)

4 Boulevard James-Fazy, 1201 Geneva (Genève), Switzerland

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