Neutrophils are cells derived from the bone marrow which are involved in acute inflammation.
They are the first cells to arrive to combat an infection and in wound healing.
They are also present in Neutrophilic dermatosis when infectious agents are not present.
They are metabolically very active in particular in the synthesis of proteins, therefore there is a lot of replication going on in the DNA – as a result of this they display progressively more and more DNA segments (poly-lobulated)
They have something to do in the development of autoimmunity: they liberate NETs (Neutrophil Extracellular Traps) of DNA to “paralyze” invaders and in doing this expose cell components which are otherwise “invisible” to the body’s own defense system.