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The Neutrophil (cell)

  • Neutrophils are cells derived from the bone marrow which are involved in acute inflammation.
    • They are the first cells to arrive to combat an infection and in wound healing.
  • They are also present in Neutrophilic dermatosis when infectious agents are not present.
  • They are metabolically very active in particular in the synthesis of proteins, therefore there is a lot of replication going on in the DNA – as a result of this they display progressively more and more DNA segments (poly-lobulated)
  • They have something to do in the development of autoimmunity: they liberate NETs (Neutrophil Extracellular Traps) of DNA to “paralyze” invaders and in doing this expose cell components which are otherwise “invisible” to the body’s own defense system.