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Treatments in use and their evidence in the treatment of Melasma (Chloasma) (Pregnancy Mask)

Evidence is classified from A (the best with the most evidence) to E:

 

 

A

  • 4% hydroquinone + 0.05% retinoic acid (RA) + 0.01% fluocinolone acetonide

 

 

B

  • 4% hydroquinone (HQ)
  • 0.1% tretinoin (RA)
  • 2% HQ + 0.05% RA + 0.1% dexamethasone (Modified Kligman formula) + 30-40% Glycolic Acid Peel (GA)
  • 4% HQ + 5% GA
  • 4% HQ + 10% GA
  • 20% Azelaic Acid
  • Adapalene
  • 4% Kojic Acid (KA) + 5% GA

 

 

C

  • 10-50% GA
  • 10% GA + 2% HQ + 20-70% GA
  • Jessner’s solution
  • 20-30% Salicylic Acid
  • 1%-5% RA
  • 50% GA + 10% KA
  • Q Switched Ruby Laser
  • Pulsed CO2 laser + Q Switched Alexandrite Laser
  • Q-Switched Alexandrite Laser
  • Q-Switched Alexandrite laser + 15%-25% Trichoroacetic (TCA) peel + Jessner’s solution

 

 

D

  • Erbium YAG laser

 

 

E

  • Dermabrasion

 

 

Source of information: Handog E. Brown Spots: Melasma Updates.2012 (02) – 20th Regional Conference of Dermatology (RCD) – Manila, Phillipines

Source of information: here