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Filaggrin is a small protein which plays an essential function in the “mortar” allowing the wall made of keratinocytes (“bricks”) to be an effective barrier to the outside world. In the Stratum Corneum of the Epidermis filaggrin exists as a precursor... READ MORE

To read the current issue of Dermatologica Helvetica, click HERE (Journal Club, Focus and “What’s Hot” in English) Published in Dermatologica Helvetica (article selection: Prof SAURAT JH, MD – Dermatologist. Geneva, Switzerland) READ MORE

Plusieurs gènes et facteurs environementaux sont impliqués mais le gène avec la plus grande influence est la filaggrine (flg).     Processus de synthèse de la filaggrine (flg): localisation génétique: chromosome 1= epidermal differentiation complex (groupe de gènes... READ MORE

Several genes and environmental factors are implicated but the one gene having the biggest role is filaggrin. This gene will be studied here     Synthesis process of filaggrin (flg): genetic localisation: chromosome 1=epidermal differentiation complex (group of genes... READ MORE

–Aging can be divided into intrinsic aging and external aging which is due to the environment. Ultraviolet light is the biggest contributor (intrinsic aging is genetic). In contrast to essentially fine wrinkles seen in intrinsic aging, photoaging is characterized by coarse... READ MORE

Summary -Topically applied sugars, in contrast to high internal sugar levels (diabetes), help a wound heal faster. This study examines the expression of Filaggrin and Claudin 1…the latter are two important proteins located in the epidermis which are important for barrier... READ MORE

Skin Structures Apocrine Gland Basement Membrane (microlayer) Eccrine Gland Epidermal Layer (Epidermis) Basal layer (Stratum Basale) Cornified layer (Stratum Corneum) Granular Layer (Stratum Granulosum) Squamous Layer (Stratum Spinosum) Dermis Hair Hair follicle Meissner... READ MORE

Skin Structures Apocrine Gland Basement Membrane (microlayer) Eccrine Gland Epidermal Layer (Epidermis) Basal layer (Stratum Basale) Cornified layer (Stratum Corneum) Granular Layer (Stratum Granulosum) Squamous Layer (Stratum Spinosum) Dermis Hair Hair follicle Meissner... READ MORE

Atopic Dermatitis: a Review Allergies to House Dust Mites (HDM) Correlated to Reduced Filaggrin (Atopic Dermatitis) Autism and Atopic Dermatitis Do Atopics Really Benefit from Allergen Immunotherapy ? How Endemic Pemphigus (Fogo Selvagem) Develops from Fly Bites Targeted... READ MORE